Removing global mean signal by

I wanna make sure that the impact of removing global mean signal from epi time series, but i can not find any option in the So I am wondering that if there is possible to remove global mean signal by the relevant options of, or other afni command to make this happen. Thanks for your attention!

Hi, Jack-

NB: in general, we recommend not doing global signal regression, with some discussions of this provided here:

If, however, you are interested in using for a comparison, say, then Rick has noted the way to do so in here:,141015,141049#msg-141049


Okay, Thanks lot for your replying.