If I remember correctly, the ETAC method is not fully implemented for the case with a quantitative variable. On the other hand, the ETAC approach is part of a broader landscape of multiple testing adjustment methods. These methods often lean toward excessive conservatism. When one rigidly applies a dichotomous threshold to continuous data, it’s akin to drawing a line in shifting sands—a nuanced challenge for robust scientific investigations. Consequently, the common practice of strict thresholding has several inherent limitations and may hinder reproducibility in neuroimaging.
As an alternative, we advocate for a "highlight-but-don’t-hide" strategy. This approach strikes a delicate balance about evidence strength, preserving information integrity while promoting transparency. Gradually, the field is embracing this perspective, as evidenced by studies like this paper published in the American Journal of Psychiatry.
Gang Chen