I estimated the seed-based functional connectivity analysis in multiple seeds (i.e. 10 seeds), and I have already estimated the 3dClustSim for the voxel-wise multiple comparisons.
I was wondering do I also need to do multiple comparisons for multiple seeds? (i.e. the corrected p-value from 3dClustSim divided by seeds number, 0.05/10)
Thanks a lot.
If you live in the conventional statistical framework, it is difficult to avoid the heavy penalty (and the watermark of 0.05/10). ROI-based analysis may help with the 10 seeds as part of the hierarchical model: https://www.sciencedirect.com/science/article/pii/S1053811919309115?via%3Dihub
Previous discussion: https://afni.nimh.nih.gov/afni/community/board/read.php?1,160410,160414