Correlation of functional connectivity with questionnaire scores

AFNI Message Board
1

Hello,

I’m trying to run a correlation analysis between brain functional connectivity and scores on a questionaire, but I can’t seem to figure out how to do it in AFNI.

I was looking at this research article, Vaghi MM, Vértes PE, Kitzbichler MG, Apergis-Schoute AM, van der Flier FE, Fineberg NA, Sule A, Zaman R, Voon V, Kundu P, Bullmore ET, Robbins TW. Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder: Evidence From Resting-State Functional Connectivity.. In the article, there were two plot diagrams looking at the correlation between functional connectivity across regions and the number of errors and attempts for a certain task (refer to attachments).

Any advice on how to do so would be much appreciated, thank you in advance!

Best,
Nick

CorrelationAFNI.PNG

CorrelationAFNI2.PNG

2

Nick,

I'm trying to run a correlation analysis between brain functional connectivity and scores on a questionaire

Is this a whole-brain population-level analysis? Is your model like the following?

FC ~ scores

If so, you may use 3dttest++.

3

Hi Gang,

Thank you for your response!

The FC that I’m investigating is between a ROI and the whole brain. Yes, the model is FC ~ scores.

Best,
Nick