Atrophy measure suggestion

Hello experts. I am currently working with elderly population. I would like to have any suggestion related to the best indicator that I should use to control/covariate for gray matter atrophy in my analysis.

Thank you for your advices!!!

This is a fairly complicated topic really. Regarding the specific questions of atrophy measures, there are a few possibilities:

  1. CSF probability. Using probabilistic segmentation from a program like 3dSeg or similar, you can generate probabilities of different tissue classes. Gray matter probability is another option here.

  2. Deformation to a normal template with Jacobian to get a compression/expansion type metric.,165536,165558#msg-165558

I have more thoughts on this, but it’s a bit much for a message board post.