There’s no need to concatenate the input data and treat the fourth dimension as time. Instead, you can use the option -covariates in 3dttest++ to include the predictor as a voxel-level covariate.
For addressing multiple testing, we suggest following the "highlight, but don’t hide" approach, as outlined in this blog post.
Gang Chen
The National Institute of Mental Health (NIMH) is part of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services.
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