Significantly mis-aligned data from align_anat_epi.py

[naailk90]

Hello everyone,

I am trying to align my anatomical to my functional however I am getting very poor results for some participants (see attached images). After alignment the anatomical looks very wonky and this was happening on quite a few participants. I have tried using different cost functions such as lpa and nmi but have had no luck. When I try the alignment on another computer with an older version of afni the alignment looks good.

Computer 1 (mis-aligned): Afni version: 19.2, AMD chipset, Ubuntu 18.04
Computer 2 (well-aligned): Afni version 18.3, Intel Chipset, MacOS High Sierra

Here is the command I was using:

align_epi_anat.py -overwrite -anat2epi -anat MPRAGE1.nii
-suffix test_al
-epi vr_base_min_outlier+orig -epi_base 0
-epi_strip 3dAutomask
-cost lpc+ZZ
-volreg off -tshift off

Thanks for any help,

Naail Khan

[dglen]

The EPI data looks fairly unstructured here. You can try the lpa, nmi or lpa+ZZ cost function. If the datasets start off far apart, also use -giant_move.